Buy Proscar Malaysia

Treatment of Benign Prostatic Hyperplasia

The most frequent disease of elderly men is benign prostatic hyperplasia (BPH). BPH is a widespread disease among 50% of men of 50 years old as well as among 80-90% men of 80 years old. The BPH symptoms are widespread among more than 23 million men. In this connection, there are two kinds of problems of this disease. They are medical problems and social problems.

The main reason of development of BPH is age-related changes of balance of androgenic hormones. A target organ for sex hormones is prostate. The main reason of prostate tumor is imbalance of androgenic hormones.

Disorder of bladder functions is a reason of pathogenesis of BPH.

The International BPH Conferences (Paris, 1993, 1997, 2000; Monaco, 1995) approved an eight-question named the International Prostate Symptom Score (IPSS). According to the International Prostate Symptom Score (IPSS) and a step scale, incomplete emptying, frequent urination, discrete urination, micturition urgency, weak urine stream, late start of stream, and night pollakiuria are possible to scale. They influent negatively on life-style of a patient making his/her life worse.

Taking into account a degree of disorder of urination, we can see a clinical presentation of disease. Intravesical obstruction at BPH develops mostly statically and dynamically. Hyperplasia of urethra tissue causes static intravesicular obstruction at BPH by mechanical squeezing of urethra. Hyperactivity of adrenoreceptors of bladder neck, of prostatic urethra, and of prostate (constriction) causes dynamic intravesicular obstruction at BPH by mechanical squeezing of urethra.

The genesis of symptoms of BPH is very complicate. Despite that, we can distinguish two kinds of symptoms of BPH. They are obstructive symptoms and irritative symptoms. Urinary retention, weak urine stream, sense of incomplete emptying, abdominal muscles tension, and drop urinary are obstructive symptoms. Progressive difficult urinary caused by hyperplasia is the main reason of obstructive symptoms. Day and night pollakiuria, micturition urgency, and urinary incontinence are irritative symptoms. The degree of a functional illness of neuromuscular system of bladder mainly cause such irritative symptoms as irritation.

Digital rectal investigation, bladder and prostate ultrasound, uroflowmetry, and analysis of prostate-specific antigen (PSA) are the main methods of physical examination.

A kidney function as well as inflammatory changes in kidneys are very important to be determined for a method of treatment to be chosen.

Nowadays, we often use the 5α-Reductase inhibitors and the α-adrenoreceptors blockers for that.

What is Proscar?

The Proscar (Finasteride) medicine is competitive 5-α-Reductase enzyme inhibitor acting in prostate cells. It was the Merck Sharp and Dohme Company who made the Proscar (Finasteride) medicine. Proscar is a pathogenetically targeted agent for hyperplasia tissues of the organ, reducing its sizes, and causing regressive symptoms of infravesicular obstruction.

The main active component of Proscar is Finasteride. Finasteride belongs to the second type of the 5α-Reductase testosterone inhibitors. Finasteride is an intracellular enzyme. It converts testosterone to androgen dihydrotestosterone and causes benign prostatic hyperplasia. Its activity is the highest.

As Finasteride reduces a level of recycling and prostatic dihydrotestosterone, its effectiveness is very high. After 4 years of treatment, halving of acute retention is the same. During this period, there is a 50% reducing risk of surgical intervention.

Urination is quicker and prostate is smaller by 1/5. There are the 67% reducing risks of the following progress of benign prostatic hyperplasia.

According to the USA research, if a patient takes Proscar against benign prostatic hypertrophy regularly, there is the 25% increasing risk of pernicious prostate diseases.

Proscar Indications

Proscar controls and acts against benign prostatic hyperplasia of increasing prostate. There are the next results of treatment:

• decreasing prostate;
• increasing speed of urination;
• decreasing number of hyperplasia symptoms;
• decreasing risk of acute urinary retention and decreasing risk of such surgical intervention as transurethral resection of the prostate and prostatectomy.

Proscar Contraindications

Acute hypersensitivity (allergy) of a patient to one of the main ancillary components is the only Proscar contraindication.

Taking Proscar with Pregnancy and Nursing

Proscar is contraindicated medicine for women during their pregnancy.

Method of Application of Proscar and Doses of Proscar

Long regular taking is a prescription of Proscar. 5 mg (1 pill) of Proscar is recommended dose to take it once a day at the same time.

The medicine is to take without regard to meals.

It is possible to take Proscar during many months or years. When diagnosed investigation, it is possible to determine, how long treatment lasts punctually and if duration of taking of Proscar depends on its individual effectiveness.

Once per 6 months, it is necessary to determine effectiveness of Proscar.

It is not necessary to correct the dose of Proscar for elder patients as well as for patients who have renal failure or hepatic failure to take it.

Proscar Overdose

There were no side effects among registered cases of overdose (400 mg once a day and 80 mg daily during 3 months).

Recommendations for overdose to neutralize are abscent.

Proscar Side Effects

There are the next Proscar side effects:

• after termination of treatment, there are often erectile dysfunction and decreased interest;
• there are rash, pruritus, medicamentous urticaria, and angioneurotic edema among allergic reactions;
• level of liver enzymes increases;
• there are also impotence, ejaculation disorder, increasing breast, breast pain, breast cancer, testis pain, and decreasing semen quality;
• ejaculate decreases.