Buy Vibramycin Malaysia

What Vibramycin is it used for?

Vibramycin is used to treat infections caused by gram-positive and gram-negative bacteria.

In particular, the use of doxycycline for the treatment of:

• Respiratory infections
• Otolaryngological infections;
• Skin and soft tissue infections;
• Gastrointestinal infections
• Infections of the genitourinary tract;
• Gynecological infections;
• Boils or red pimples due to rosacea;
• Chronic and aggressive periodontitis (doxycycline is used as a periodontal gel).

Warnings

Doxycycline can cause photosensitivity reactions. Therefore, exposure to sunlight and UV rays should be avoided during therapy with the antibiotic. Treatment with doxycycline can promote the development of superinfections by bacteria that are resistant to doxycycline itself or to fungi, such as vaginal candidiasis or infection with Clostridium difficile, which can lead to the appearance of pseudomembranous colitis.

Vibramycin therapy can - especially at high doses and over a long period - lead to changes in liver function. Regular checks are therefore necessary. Caution should be exercised when administering doxycycline to patients with renal insufficiency. Indeed, renal excretion of doxycycline may decrease in these patients, leading to an increase in its plasma concentration.

Increasing the plasma antibiotic concentration can in turn lead to liver damage.

Doxycycline can cause esophagitis and even severe esophageal ulcers.

Therefore, it is recommended to take doxycycline with plenty of water and to stay in an upright position for at least an hour after administration of the antibiotic.

If doxycycline is administered over a long period of time, regular blood tests and liver and kidney function checks should be performed.

Like all tetracyclines, doxycycline can settle in teeth and bones during the development and growth phase, cause hypoplasia and change the tooth color (the teeth can take on a yellow-brown color). Therefore, the antibiotic should not be administered during pregnancy, lactation and in children under 12 years.

Great care should be taken when administering doxycycline to patients with preexisting myasthenia gravis (a neuromuscular disorder).

Patients who are already receiving oral anticoagulants and need to start treatment with doxycycline may need to adjust the anticoagulants they are given.

Interactions

Taking doxycycline and the following medicines or foods at the same time may decrease the absorption of doxycycline itself:

1. Antacids containing aluminum, calcium and magnesium;
2. Milk and milkproducts;
3. Products containing iron salts;
4. Preparations containing zinc and bismuth.

Vibramycin can increase prothrombin time in patients receiving warfarin or other oral anticoagulants. Therefore, the dose of oral anticoagulant administered may need to be reduced during treatment with the antibiotic.

Doxycycline and penicillins can mutually impair their antibacterial activity. Therefore, the association of these two types of antibiotics must be avoided.

Phenobarbital, carbamazepine and phenytoin (medicines used to treat epilepsy) can reduce the plasma half-life of doxycycline.

The half-life of doxycycline can also be reduced by taking alcoholic beverages at the same time.

Vibramycin can reduce the effectiveness of oral contraceptives. Doxycycline can increase the plasma concentration of cyclosporin (an immunosuppressant used to prevent rejection in transplants).

Concomitant use of doxycycline and systemic retinoids should be avoided as there is an increased risk of developing benign intracranial hypertension. Vibramycin can interfere with laboratory tests to determine catecholamines in urine.

In any case, your doctor must be informed if you are taking or have recently taken any kind of medication, including over-the-counter medications and herbal and / or homeopathic products.

Side effects

Doxycycline can cause different types of side effects, although not all people experience them. This depends on the different sensitivity that each individual has to the drug. Therefore, it is not said that the undesirable effects all occur with the same intensity in each patient.

The main side effects that may occur during treatment with doxycycline are listed below.

Allergic reaction

Vibramycin can cause allergic reactions in sensitive patients. Such reactions can take the form of:

• Baby-enoch purpura;
• Hypotension;
• Angioedema;
• Peripheral edema;
• Tachycardia;
• Pericarditis;
• Dyspnea;
• Serum reaction;
• Drug rash with eosinophilia and systemic symptoms (also known as DRESS syndrome);
• Anaphylaxis.

Blood and lymphatic system disorders

Doxycycline therapy can promote the start of:

• Neutropenia, d. H. Decrease in the number of neutrophils in the bloodstream;
• Eosinophilia, i.e. H. The increase in the number of eosinophils in the bloodstream;
• Thrombocytopenia, i.e. H. decrease in the number of platelets in the blood;
• Hemolytic anemia.

Gastrointestinal pathologies

Vibramycin treatment can cause:

• Nausea or vomiting
• Dyspepsia;
• Pseudomembranous colitis due to superinfections with Clostridium difficile;
• Inflammation of the esophagus;
• Ulcers of the esophagus;
• Inflammation of the intestine
• stomach pain
• Diarrhea;
• Dysphagia;
• Pancreatitis;
• Glossitis.

Hepatobiliary pathologies

Doxycycline can cause changes in liver function, jaundice and hepatitis.

Endocrine pathologies

Treatment with doxycycline can lead to microscopic brown pigmentation of the thyroid gland.

Metabolism and nutrition disorders

Vibramycin therapy can promote the occurrence of anorexia and porphyria.

Skin and subcutaneous tissue disorders

Doxycycline treatment can cause:

• Photosensitization reactions;
• Erythematous or maculopapular rashes;
• Erythema multiforme;
• Stevens-Johnson syndrome;
• Peeling dermatitis;
• Toxic epidermal necrolysis;
• Photo onycholysis.

Musculoskeletal and connective tissue disorders

Vibramycin therapy can cause:

• Myalgia;
• Arthralgia;
• Worsening of the symptoms of myasthenia gravis in patients with myasthenia gravis.

Other side effects

Other side effects that may occur during treatment with doxycycline are:

• a headache
• Inflammation of the nose and throat
• Sinusitis;
• Difficulties swallowing;
• Benign intracranial hypertension;
• Redness;
• Hypertension or hypotension
• Anogenital candidiasis;
• Dry mouth
• Tinnitus, ie a hearing disorder characterized by the perception ofcwhistling, rustling, humming, clinking, etc.
• Increased blood urea and blood urea;
• Worsening of symptoms of systemic lupus erythematosus in patients with this.

Side effects related to the use of periodontal gel

After applying the periodontal gel based on doxycycline, the gums can swell and you can perceive a taste similar to that of chewing gum.

Overdose

If you suspect that you have overdosed on doxycycline, you should inform your doctor immediately and go to the nearest hospital.

In the event of an overdose, gastric lavage can be useful to remove excess antibiotic from the body.

Mechanism of action

Doxycycline exerts its bacteriostatic antibacterial activity (i.e. it can inhibit the growth of bacterial cells but not kill them) by disrupting the protein synthesis of bacteria.

Proteins in bacterial cells are synthesized thanks to organelles called ribosomes. These organelles are made up of ribosomal RNA and proteins that are associated to form two subunits: the 30S subunit and the 50S subunit. The role of the ribosome is to bind and translate the messenger RNA from the cell nucleus and to synthesize the proteins for which it codes.

Vibramycin is able to bind to the 30S ribosomal subunit, preventing the binding of messenger RNA to the ribosome itself. In this way, protein synthesis is blocked.

Method of application - dosage

Doxycycline is available for oral administration in the form of tablets or hard capsules. It is also available as a periodontal gel.

The dosage and duration of treatment must be determined by the doctor depending on the type and severity of the infection to be treated. Below is some guidance on the doses of the drug that are normally used in therapy.

Oral administration (tablets or capsules)

Tablets with 100 mg doxycycline are usually used to treat infections of various types.

The usual dose of doxycycline is 200 mg on the first day of treatment. From the second day, however, the usual dose, according to the doctor, is 100-200 mg of the drug.

The tablets should be taken whole with plenty of water and at least one hour before bedtime to avoid possible irritation of the esophagus.

Capsules containing a smaller amount of doxycycline than those contained in the tablets described above are usually used to treat pimples and red pimples caused by rosacea.

In this case, the usual dose of doxycycline is 40 mg to be taken once a day, generally in the morning.

The capsules must be taken whole and with plenty of water to avoid possible irritation of the esophagus

Regardless of the administration of the tablets or capsules, doxycycline should not be taken at the same time as milk or milk products.

Periodontal gel

Periodontal gel based on doxycycline should only be administered by dentists in periodontal pockets and using a special device.

After applying the gel for at least seven days, brushing your teeth in the treated area should be avoided.

Pregnancy and breast feeding period

Vibramycin can settle in the teeth and bones that form in the fetus and cause growth problems. Therefore, the use of the drug by pregnant women should be avoided.

Doxycycline is excreted in breast milk and can harm the baby. Breastfeeding mothers should therefore not take the antibiotic.

Contraindications

The use of doxycycline is contraindicated in the following cases:

• In patients with known hypersensitivity to doxycycline itself;
• In patients with known hypersensitivity to other tetracyclines;
• In patients with obstructive diseases of the esophagus, such as narrowing or achalasia of the esophagus;
• In children under 12 years;
• During pregnancy;
• During breastfeeding.